Endocrine Abstracts

BackgroundPosterior pituitary ectopia is a rare congenital condition that consists of the abnormal position of the distinctly hyperintense signal suggestive of the posterior pituitary gland on magnetic resonance imaging. The classical features include the ectopic location of the posterior pituitary gland, pituitary stalk abnormalities and associated clinical manifestations related to isolated growth hormone deficiency. In rare cases, some patients suffer...

Introduction: Immune-checkpoint inhibitors (ICIs) have revolutionised cancer treatment, offering superior efficacy compared to traditional chemotherapy. The use of immune checkpoint inhibitors has been associated with the occurrence of multiple endocrine immune-related adverse events (irAEs), such as primary hypothyroidism, thyroiditis, primary adrenal insufficiency, type 1 diabetes mellitus, and hypophysitis. In certain instances, these irAEs may necessitate the discontinuati...

Introduction: Acromegaly is a progressive disorder caused by excess growth hormone (GH), usually due to a GH-secreting pituitary adenoma, associated with an increased risk of cancer-related mortality. Insulin-like growth factor 1 (IGF-1) has been involved in tumor development by promoting cell proliferation and inhibiting apoptosis. Multiple myeloma (MM), a plasma cell neoplasm, has been suggested to have a potential link to IGF-1 in its pathogenesis.Cas...

Introduction: Recent studies have revealed that thyroid autoimmunity and thyroid cancer may coexist, although a pathogenic relationship has not been clearly established. Graves’ disease (GD) is an autoimmune thyroid disease and is considered the most common cause of hyperthyroidism. Thyroid cancer is the most common malignancy of the endocrine system and represents the eighth most diagnosed cancer worldwide. Although in patients with GD, the presence of thyroid nodules is...